8.1 Metabolic Pathways

Metabolism

Cellular processes such as building and breaking down complex molecules occur through stepwise chemical reactions. Some of these chemical reactions are spontaneous and release energy; whereas others require energy to proceed. Just as living things must continually consume food to replenish what they have used, cells must continually obtain more energy to replenish that which the many energy-requiring chemical reactions  use. All of the chemical reactions that transpire inside cells, including those that use and release energy, are the cell’s metabolism.

Anabolic and Catabolic Pathways

A metabolic pathway is a linked series of biochemical reactions that convert a molecule or molecules, step-by-step, through a series of metabolic intermediates, into a final product or products.

Anabolic pathways require an input of energy to synthesize complex molecules from simpler ones. Synthesizing sugar from CO2 during photosynthesis is one example. Other examples are synthesizing large proteins from amino acid building blocks, and synthesizing new DNA strands from nucleic acid building blocks. These biosynthetic processes are critical to the cell’s life, take place constantly, and demand energy that ATP and other high-energy molecules provide.

Formation of a peptide bond between two amino acids
Joining two amino acids together to make a dipeptide is an example of an anabolic reaction. Building larger molecules from smaller molecules requires energy. (Peptide bond formation by Yikrazuul is in the public domain).

Catabolic pathways involve degrading (or breaking down) complex molecules into simpler ones. An example of a catabolic pathway is the breakdown of glucose during cellular respiration. Molecular energy stored in the chemical bonds of glucose are harvested in such a way that it can produce ATP. Other energy-storing molecules, such as fats, also break down through similar catabolic reactions to release energy and make ATP.

 

Lactose breaking down into galactose and glucose
Lactose degradation is an example of a catabolic reaction. Lactose is broken down into glucose and galactose. An enzyme called lactase catalyzes this process in cells. This reaction releases energy stored in the covalent bond between galactose and glucose. The name of the enzyme is written over the arrow to indicate that it participates in, but is not changed by, this reactions. (Lactose degradation by Melissa Hardy is in the public domain).

It is important to know that many of the chemical reactions that together constitute a metabolic pathway require a protein called an  enzyme to facilitate or catalyzes each step. Enzymes are important for catalyzing all types of biological reactions—those that require energy as well as those that release energy.


Text adapted from OpenStax Biology 2e and used under a Creative Commons Attribution License 4.0.
Access for free at https://openstax.org/books/biology-2e/pages/1-introduction
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